Project Description Components:
- Project title: Examining the role of the tumor microenvironment in early onset colorectal cancer
Colorectal cancer (CRC) is a major health burden, ranking as the second most common cancer and the third leading cause of cancer-related death in the US among individuals under 50 years old (early onset). While CRC incidence and mortality have decreased in those 50 and older (late onset) during the past 30 years, the opposite trend has been observed in younger adults, with incidence increasing from 8.6 to 12.9 per 100,00 from 1992 to 2018 in patients less than 50 years old. Recent studies have revealed little difference in the mutational profile of late onset versus early onset colorectal cancer. The goal of this study is to evaluate the tumor microenvironment of early onset versus late onset colorectal cancer using patient tissue samples and patient derived 3D tumor organoid model systems (in vitro culture system).
Student tasks and responsibilities:
This is a part-time undergraduate research position (volunteer) on a wet lab project. The researcher would need to commit 4-6 hours a week during the semester.The student researcher will work closely with a physician post-doctoral research fellow in the Gabre Lab (physician scientist) and assist in the creation of 3D tumor organoid model systems from patient samples, extraction of DNA and RNA from patient tumor samples and organoids, and assist in the embedding of samples for staining.
- Minimum qualifications: some previous 2D cell culture experience is preferred but not required.
Contact Professor Joel Gabre, firstname.lastname@example.org, with any questions.